CHLORHEXIDINE

CHLORHEXIDINE BASE

TYPICAL CERTIFICATE OF ANALYSIS
TEST	SPECIFICATION	RESULT
APPEARANCE	WHITE POWDER	WHITE POWDER
IR SPECTRUM	TO MATCH REFERENCE STANDARD	COMPLIES
MELTING POINT	132-136 CELCIUS	132-134 CELCIUS
RESIDUE ON IGNITION	NOT MORE THAN 0.1 % W/W	0.05 % W/W
CHLOROANILINE (PCA)	NOT MORE THAN 60 PPM	COMPLIES
LOSS ON DRYING	NOT MORE THAN 0.5 % W/W	0.2%
ASSAY	BY HPLC : NOT LESS THAN 98 % AND NOT MORE THAN 102 % BY TITRATION : NOT LESS THAN 98 % AND NOT MORE THAN 102 %	BY HPLC : 99.5 % BY TITRATION : 99.8 %
COLOUR TEST	ABSORBANCE NOT MORE THAN 0.03 AT 480 NM	.008

MATERIAL SAFETY DATA SHEET

CHLORHEXIDINE BASE

SECTION I

Chemical Name: Chlorhexidine Gluconate Solution

SECTION II - HAZARDOUS INGREDIENTS

Ingredients	CAS #	%	TLV	PEL	UNITS
Chlorhexidine Gluconate Solution	55-56-1	100

SECTION III - PHYSICAL DATA

Boiling Point (°F)	N/A	Specific Gravity (H₂O=1)	N/A
Vapor Pressure (MM Hg)	N/A	Percent Volatile by Vol.	N/A
Vapor Density (Air=1)	N/A	pH	N/A
Solubility in Water	miscible	Evap Rate (Ether = 1)	N/A
Appearance and Odor	white	Form	powder

SECTION IV - HAZARDOUS REACTIVITY

Instability - Stable.

Incompatibility - Solutions containing inorganic anions such as saline.

Decomposition - N/A

Polymerization - Polymerization will not occur.

SECTION V - FIRE AND EXPLOSION HAZARD DATA

Flash Point - N/A

Flammable Limits

LEL - N/A

UEL - N/A

Fire and Explosion Hazards - Presence of solid oxidizers.

Extinguishing Media - Water spray, foam, Carbon Dioxide and dry chemical.

Special Fire Fighting Procedures - Use supplied air respirators.

SECTION VI - HEALTH HAZARD INFORMATION

Eye - Corrosive to eyes.

Skin - Primary skin irritant, could cause allergic reaction in some people.

Inhalation - Nasal discomfort, high concentrations may cause headaches.

First Aid

Eyes: Immediately flush eyes with large amounts of water for at least 15 minutes while holding the eyelids open. Get prompt medical attention.

Skin: Immediately remove contaminated clothing; wash skin with large amounts of water for at least 15 minutes. Get prompt medical attention.

Inhalation: Unlikely route of exposure,

Ingestion: Give two glasses of water. Do induce vomiting. Contact local Poison Control Center or physician immediately!

SECTION VII - SPILL or LEAK PROCEDURES

Procedures - Contain spill with non reactive absorbent such as vermiculite.

Waste Disposal Method - Dispose of in accordance with Local, State, and Federal Regulations.

SECTION VIII - SPECIAL PROTECTION INFORMATION

Respiratory - N/A.

Eyewear - Safety Glasses.

Clothing/Gloves - Plastic rubber.

Ventilation - Local exhaust may be necessary under some handling/use conditions. Specific needs should be addressed by supervisory or health safety personnel.

SECTION IX - TRANSPORTATION INFORMATION

Shipping Information:

DOT-Domestic Ground Transportation

Proper Shipping Name Non-Hazardous Material

CHLORHEXIDINE DIGLUCONATE IP/BP/EP

CHLORHEXIDINE DIGLUCONATE 20 % w/v Typical Certificate of Analysis
TEST	SPECIFICATION	RESULT
CHARACTERS	AN ALMOST COLOURLESS OR PALE –YELLOWISH LIQUID , MISCIBLE WITH WATER , SOLUBLE IN ACETONE AND IN ALCOHOL	AN ALMOST COLOURLESS LIQUID , MISCIBLE WITH WATER ,SOLUBLE IN ACETONE AND IN ALCOHOL
IDENTIFICATION	FIRST IDENTIFICATION : A,B SECOND IDENTIFICATION : B,C,D.	COMPLIES
RELATIVE DENSITY	1.06-1.07	1.067
PH	DILUTE 5.0 ML TO 100.0ML WITH CARDON DIOXIDE FREE WATER R . THE PH OF THE SOLUTION IS 5.5 TO 7.0	5.73
CHLOROANILINE (PCA)	TO COMPLY WITH BP TEST	COMPLIES
RELATED SUBSTANCES	TO COMPLY WITH B.P TEST TOTAL IMPURITY SHOULD BE LESS THAN 3 %	COMPLIES
ASSAY	CHLORHEXIDINE DIGLUCONATE SOLUTION IS AN AQUEOUS SOLUTION WHICH CONTAINS NOT LESS THAN 190 G/L AND NOT MORE THAN 210 G/L OF 1,1' HEXAMETHYLENENEBIS [5-(4-CHLOROPHENYL)-BIGUANIDE]di(D-DIGLUCONATE ).	199.0 G/L